Liver cancer affects about one million people per year worldwide, being the second leading cause of cancer mortality. The incidence of its two main types, hepatocellular carcinoma (HCC), followed by intrahepatic cholangiocarcinoma (ICC), is one of the few common cancers with increasing mortality rates in most regions of the world. The study of LC etiology, mechanisms and strategies for prevention remains therefore a global priority, though it is often neglected in terms of research and development efforts in North America and Europe. The main challenge for HCC is to understand the role of nutritional and metabolic factors in cancers not related to hepatitis B (HBV) and C virus (HCV) infection, and their interaction with HBV and/or HCV; the etiology of ICC is still largely unexplained. Various consortia of epidemiological studies have been established during the last two decades, to pool and analyze data on risk factors for various cancers, which have produced important novel results, but no such effort has yet been proposed for LC.


Next meetings

The next ILCEC meeting will be held during the ACC General Membership Meeting in Nagoya, September 4-5, 2018 (




This consortium of case-control and cohort investigations examines in an uniquely large dataset the role of several risk factors for liver cancer including - among others - dietary components and patterns, tobacco and alcohol use, overweight/obesity, physical activity, socio-economic status, history of selected diseases, use of medications, and occupational exposures, and their interactions with HBV and HCV infection. With reference to genetic factors, replication studies are conducted by focusing on genetic variants identified in previous genome-wide association studies. Further, haplotyping of the confirmed variant regions and of genes functionally related with them are performed to verify potential biological interactions. Genetic analyses also address gene-environment interactions.

The overarching purpose of the ILCEC is to provide a comprehensive picture on lifestyle and genetic correlates of liver cancer.